Biochem/physiol Actions

Target IC₅₀: 280 nM, 170 nM, 20 nM, and 130 nM against Src, Fyn, Yes, and Lyn.

Reversible: yes

Product competes with ATP.

Cell permeable: yes

General description

A potent, cell-permeable, reversible, and ATP-competitive inhibitor of Src-family protein tyrosine kinases. Inhibits Src (IC₅₀ = 280 nM) as well as closely related kinases Fyn (IC₅₀ = 170 nM), Yes (IC₅₀ = 20 nM) and Lyn (IC₅₀ = 130 nM). The inhibition is competitive with respect to ATP. Has only a trivial effect on Lck (IC₅₀ = 6.88 µM). Does not affect the activity of PDGF-β receptor kinase (IC₅₀ ≥10 µM) and IGF-1 receptor kinase (IC₅₀ ≥20 µM).

A potent, cell-permeable, reversible, and ATP-competitive Src family kinase inhibitor. Inhibits Src (IC₅₀ = 280 nM) as well as closely related kinases such as Fyn (IC₅₀ = 170 nM) and Yes (IC₅₀ = 20 nM) and Lyn (IC₅₀ = 130 nM). Acts as a weak inhibitor of Lck (IC₅₀ = 688 µM) and PDGF receptor kinase (IC₅₀ >10 µM). A 10 mM (500 µg/135 µl) solution of SU6656 (Cat. No. 572636) in DMSO is also available.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Bowman, T., et al. 2001. Proc. Natl. Acad. Sci. USA98, 7319.Blake, R.A., et al. 2000. Mol. Cell. Biol.20, 9018.

Packaging

1 mg in Plastic ampoule

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)